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home start here tp53 information general information historical aspects tp53 knowledge center tp53 database mutation database the tp53 cell line compendium mutant loss of activity database tp53 and cancer tp53 : recommended guidelines seshat our work the lab publications contact us joining the lab news all about ... site news events workshop image gallery search site tp53 community links welcome to the novel tp53 website after 20 years of existence with more than 4 million pages visited, the old tp53 website ( http://p53.free/.fr) has been closed and has been replaced by its successor ( p53.fr ) the new tp53 website has been launched with a novel design, updated information and improved readability. this site still includes former features, such as tp53 history, tp53 information or the tp53 mutation database, but these features have been updated to take into account the most recent developments in this exciting field. novel features and tools include the tp53 cell line compendium, a revised version of tp53 mutation assessor and the last issue of the umd tp53 database with more than 80,000 tp53 mutants (2017 release). human mutation 2014 tp53 special issue human mutation 2014 tp53 special issue soussi, t. (2014) the tp53 gene network in a post-genomic era human mutation 2014 tp53 special issue soussi, t. (2014) locus-specific databases in cancer: what future in a post-genomic era? the tp53 lsdb paradigm. human mutation 2014 tp53 special issue leroy b, anderson m, soussi t (2014) tp53 mutations in human cancer: database reassessment and prospects for the next decade. human mutation 2014 tp53 special issue kamihara, j., rana, h.q., and garber, j.e. (2014) germline tp53 mutations and the changing landscape of li-fraumeni syndrome human mutation 2014 tp53 special issue malcikova j, pavlova s, kozubik ks, pospisilova s (2014) tp53 mutation analysis in clinical practice: lessons from chronic lymphocytic leukemia. human mutation 2014 tp53 special issue eischen cm, lozano g (2014) the mdm network and its regulation of p53 activities: a rheostat of cancer risk. human mutation 2014 tp53 special issue nguyen, t.a., menendez, d., resnick, m.a., and anderson, c.w. (2014). mutant tp53 posttranslational modifications : challenges and opportunities . human mutation 2014 tp53 special issue candi, e., agostini, m., melino, g., and barnassola, f., (2014). how the tp53 family proteins tp63 and tp73 contribute to tumorigenesis : regulators and effectors. human mutation 2014 tp53 special issue candi e, agostini m, melino g, and barnassola f (2014). tp53 mutants in the tower of babel of cancer progression. human mutation 2014 tp53 special issue donehower la (2014). insights into wild-type and mutant p53 functions provided by genetically engineered mice. human mutation 2014 tp53 special issue leroy b, girard l, hollestelle a, minna jd, gazdar af, soussi t (2014). analysis of tp53 mutation status in human cancer cell lines: a reassessment. human mutation 2014 tp53 special issue soussi t, leroy b, taschner pe (2014). recommendations for analyzing and reporting tp53 gene variants in the high throughput sequencing era. please check our new recommendations for the analysis and the validation of tp53 mutation in human cancer: leroy, b., ballinger, m. l., baran-marszak, f., bond, g. l., braithwaite, a., concin, n., donehower, l. a., el-deiry, w. s., fenaux, p., gaidano, g., langerød, a., hellstrom-lindberg, e., iggo, r., lehmann-che, j., mai, p. l., malkin, d., moll, u. m., myers, j. n., nichols, k. e., pospisilova, s., ashton-prolla, p., rossi, d., savage, s. a., strong, l. c., tonin, p. n., zeillinger, r., zenz, t., fraumeni, j. f., taschner, p. e., hainaut, p., and soussi, t. (2017). recommended guidelines for validation, quality control, and reporting of tp53 variants in clinical practice . cancer res 6, 1250-1260. available as an open access here : a special issue of human mutation has been released: the tp53 gene network in the post-genomic era this special issue on tp53 propels the tp53 gene into the post-genomic era. several fundamental features of wild-type and mutant proteins and their modifications are reviewed, as well as animal models and clinical aspects such as recommendations for patient care. the complex structure of this gene warrants innovative strategies to infer a more accurate status of human tumors. recommendations and guidelines for reporting and annotating tp53 variants are also provided to help researchers generate standardized data that are easy to understand, analyze, and exchange across various cancer variant databases. a graphical summary of the various articles is presented above. all articles are available on open access and can be downloaded here: http://onlinelibrary.wiley.com/doi/10.1002/humu.2014.35.issue-6/issuetoc site latest news the novel tp53 web site 28 october 2017 the 16th p53 international workshop image gallery 08 august 2014 more in site news literature highlights recent publications on tp53 or cancer genomics: a personal choice read more ... events this section provides key information about a selection of cancer meetings and workshops happening throughout the world. read more ... © 2017 thierry soussi pubmed human mutation photos libres go to top
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